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This article reviews the mechanisms by which micronized purified flavonoid fraction (MPFF; Daflon 500 mg) acts on symptoms as well as on edema in patients with chronic venous disease, in the light of new advances in the understanding of the pathophysiology of this chronic condition.

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In both sexes, peak prevalence occurred between age 45-65 years and the development of hemorrhoids before the age of 20 years was unusual.

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Background: Calcium dobesilate and purified, micronized flavonoid fraction of diosmin, 2 products used in the treatment of chronic venous insufficiency in the lower limbs, have been shown in open-label, placebo-controlled studies to improve symptoms of acute hemorrhoidal episodes.

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