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This article reviews the mechanisms by which micronized purified flavonoid fraction (MPFF; Daflon 500 mg) acts on symptoms as well as on edema in patients with chronic venous disease, in the light of new advances in the understanding of the pathophysiology of this chronic condition.

Serum Alanine Transaminase (ALT) and the result was 21 which is normal range.

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In both sexes, peak prevalence occurred between age 45-65 years and the development of hemorrhoids before the age of 20 years was unusual.

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Venous hypertension is the result of impaired venous return.

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While the MSL fat grows, normal fat and muscle can undergo wasting which can be confused with a partial lipodystrophy ().

Background: Calcium dobesilate and purified, micronized flavonoid fraction of diosmin, 2 products used in the treatment of chronic venous insufficiency in the lower limbs, have been shown in open-label, placebo-controlled studies to improve symptoms of acute hemorrhoidal episodes.

Probiotics, or "friendly" bacteria, such as lactobacillus and bifidus, can help prevent and treat hemorrhoids.

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Varicosities usually start at points where superficial veins communicate with deep veins, particularly at the saphenofemoral and saphenopopliteal junctions and in the perforating system, because of valvular incompetence.

There are also physical and chronic disorders in the muscles and the tendons, moreover and problems in contracting muscular tissue may be present in such people.

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Directive 119 of January 1st, 1995, by giving preference to surgical treatment over conservative therapy, has prompted an increase in the number of surgical procedures, which rose to 136 075 varicose vein ligations and stripping procedures in 2009 (according to official data).

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