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I am 20 years old currently, but when I was 16 I was diagnosed with polycystic ovarian syndrome. I have always struggled with weight, but nothing major. I go up and down, I am 5'7 and I am always between 135-160. I was put on Yasmin and took it for 3 years, and then I went off it for 2 months. While I was off the Yasmin, I had no acne. After 2 months, I went back on because my prescription was refilled, and my skin was TERRIBLE. It also scarred. I went to my gyn after 3 months of vigorously trying to get rid of the acne, and she kept me on my Yasmin while adding Metformin and Spironolactone. This combination worked wonders after 3 days! Lost weight, NO new acne, and my cystic pimples have DISAPPEARED.

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Indeed, given its steroidal backbone and structural similarity to progesterone, it would not be unexpected if abiraterone emerged as an AR agonist in certain subsets of CRPC ().

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This is by far the best thing I have used for hormonal acne.

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Spironolactone takes up to 3 months to have its full effect, at which point I will sometimes decrease the dose or may increase the dose of Spironolactone if necessary.

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